ملف المستخدم
صورة الملف الشخصي

زينب محمد فرحان

إرسال رسالة

التخصص: ماجستير علوم التحليلات المرضية الاختصاص

الجامعة: دائرة صحة ذي قار/مستشفى الإمام الحسين التعليمي عليه السلام

النقاط:

37.5
معامل الإنتاج البحثي

الخبرات العلمية

  • Bachelor of Science in Pathology, specialization in Pathological Analysis and Master of Science in Pathology, specialization in Histopathology... and a reviewer in many local and international journals and holds the title of Assistant Professor
  • مقيم علمي في المؤتمر بابل للعلوم الهندسية والتكنولوجيا
  • مقيم علمي في المؤتمر العلمي الدولي الخامس للتكنولوجيا في جامعه ذي قار

الأبحاث المنشورة

A histopathological study to evaluate the role of immunohistochemical technique for evaluating follicular thyroid cancer among cancer patients in Dhi Qar Governorate

المجلة: International Journal of Advanced Research in Medicine

سنة النشر: 2024

تاريخ النشر: 2024-07-26

Background: Despite rising rates of well-differentiated thyroid cancer, follicular thyroid carcinoma is becoming less common. This paper examines the evolution of morphological and immunohistochemical diagnostic criteria to explain why this phenomenon occurred. Follicular thyroid tumors. This article will cover the differences between follicular carcinoma, follicular adenoma, follicular variant of papillary carcinoma, and poorly differentiated carcinoma. It will also discuss the newly defined categories of follicular tumors: follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential, and well-differentiated carcinoma, not otherwise specified. Finally, interesting molecular biomarkers will be examined in relation to histopathological categorization for their prognostic and therapeutic implications

A histochemical study to evaluate the role of some isoindoline-1-one compounds γ-lactam compounds on the biological functions of adult laboratory rabbits

المجلة: The International Innovations Journal of Applied Science

سنة النشر: 2024

تاريخ النشر: 2024-03-26

This study is concerned with the synthesis and characterization of derivatives of the isoindoline-1-one γ-lactams (c-d), were prepared by reacting Phenyl succinic anhydirde with the appropriate Schiff base (a-b), in the presence of γ-lactam compounds were prepared from the reaction between 2-chloro benzoyl chloride with imines (a-b) in the prescence Phenyl lithium under (N2) atm (-5) in THF solvent to yielded product γ-lactams. reaction was verified by thin layer chromatography (TLC), and the formed compounds were identified by NMR, IR, mass spectra. The proposed reaction for their formations . In the current study, 30 white male rabbits with an average weight of 250 g were used, they were randomly divided into three groups as follows, group (1) includes 10 untreated rabbits as a control group, group (2) consists of 10 rabbits treated with the first compound. A) at a concentration of 30 mg | kg | day, group (3) consisted of 10 rabbits that were treated with the second compound (B) at a concentration of 30 mg | kg | day. The dose was determined based on body weight and all animals received the doses by oral administration for thirty days Blood samples were taken at the end of the experiment by a direct heart stab and the samples were centrifuged, and they were kept in special tubes at 4°C until the start of measuring the industrial and enzyme functions of the kidney. % of all mice until the start of preparing the tissue sections and studying the effect of the two compounds. The two compounds varied in their effect on some biochemical parameters related to the manufacturing and enzyme function of the kidney. Histologically, the results indicated that treatment with compound A did not show any histological changes, while the results of treatment with compound B showed enlargement of some kidney cells and atrophy of the nuclei of other cells with cases of fibrosis, blood congestion and infiltration of inflammatory cells compared to control group.

pathochemical study to assess the level of vitamin B12 and magnesium in patients with type 1 and type 2 diabetes mellitus in Thi-Qar governorate.

المجلة: Journal of Medical and Life Science

سنة النشر: 2024

تاريخ النشر: 2024-02-26

Objective: In this research paper, we examine how treating patients with type 1 and type 2 diabetes with vitamin B12 and magnesium affects both insulin and non-insulin levels. The Glycated hemoglobin (HbA1c) marker, which is one of the fundamental and clinical markers to monitor in the control of type 2 diabetes mellitus patients (T2DM and type 1 diabetic mellitus), is also highlighted and discussed in this study. Methods: From February to March 2023, a cross-sectional study was done at the Medical Labs Research Center of Al-Hussein Teaching Hospital in Nasiriyah Governorate. Our research included 40 people with type 1 and type 2 diabetes. Before fasting, a physical examination, a thorough medical history, and blood samples were obtained. Following a 12-hour fast, all blood samples were collected. Results: Except for the B12 and Mg++ levels being significantly higher in DM1 patients in both the first and second age groups and the third age group of DM1 patients being significantly lower at p. value 0.05, we conclude from this study's two-way ANOVA test and t-test that cumulative sugar is unaffected by age or type of sugar. Conclusions: Our findings indicate that both concentrations of B12 and Mg++ increased significantly in patients with DM1 than DM2 at p. value < 0.05. These findings call for more research on a wider population to look at the source of the deficit and the effectiveness of B12 supplementation in these patients.

Estimation of thyroid hormone and adipocytokine levels in men with obesity and type 2 diabetes in Thi-Qar Governorate

المجلة: International Journal of Advanced Chemistry Research

سنة النشر: 2024

تاريخ النشر: 2024-01-26

Background: Obesity is a common disease around the world and is considered a risk factor for developing type 2 diabetes, which is characterized by the body’s lack of response to the insulin produced, which leads to high blood sugar levels. Thyroid hormones also affect metabolic processes in the body and may play a role in causing obesity. This study is concerned with knowing the levels of thyroid hormones and adipocytokine levels and the relationship between them, to find out the causes of obesity and diabetes, or to identify risk factors for the purpose of developing solutions for them and eliminating complications and future problems caused by both diabetes and obesity. Aims of the study: The relationship between thyroid hormones and adipocytokine levels and their effect on obesity and diabetes in men. Methodology: A study using a case-control design. The study comprised a sample of 100 men who were obese and diagnosed with type 2 diabetes, alongside a control group of 50 men who were in good health. From October 10, 2023 to October 1, 2024, data was gathered from patients at Al-Habbobi Teaching Hospital, including their age, weight, and height. Fasting blood sugar was quantified using a spectrophotometer, HbA1c levels were measured using the AVIAS-6 device, and adipocytokines were assessed using the enzyme-linked immunosorbent assay. The levels of C-peptide and thyroid hormones were measured using COBAS. Results: The results showed that there is no statistical significance in age between the two groups. There is also a statistical significance in the body mass index between the two groups. The results showed that the levels of leptin, resistin, and adiponectin showed a significant decrease in the obese group compared to the control group. FT4 levels also showed a significant decrease in the patient group compared to the control group. The levels of TSH and Free T3 were significant increase in obese group. Regarding cholesterol, HDL, and LDL, there are no statistical differences between the two groups. As for Triglyceride-VLDL, HbA1c, fasting blood sugar, and C-peptide, the results showed a significant increase in the obese group compared to the control group. Conclusion: Adipocytokine levels showed a significant decrease in the obese diabetic group, and this indicates its role in controlling sugar levels and insulin sensitivity. As for thyroid hormones, the results showed a significant decrease in thyroxine levels. This indicates the effect of adipocytokin on thyroxine levels and that the relationship between them has an effective role in controlling obesity and diabetes.

Assessing the relation between some biochemical variables and vitamin D in patients with recurrent chronic arthritis

المجلة: Journal of Pharmaceutical Negative Results

سنة النشر: 2022

تاريخ النشر: 2022-07-24

There are numerous biochemical markers that are either directly or indirectly related to the pathogenesis of rheumatoid arthritis (RA), which is characterized by both local and systemic effects of inflammation. By assessing the level of vitamin D in the serum of patients with recurrent arthritis, we conclude from this study that vitamin D is one of the vitamins that contribute to the emergence of the process of recurrent arthritis. The markers of disease activity such as erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) were also measured. The study included (60) patients with rheumatoid arthritis of both sexes, with the number of females (22) ranging in age from (31-70) years and the number of males (18) ranging in age from (31-70) years. They were also compared to a control group of (20) healthy men and women, divided into ten (10) males and ten (10) females. For both sexes, their ages ranged from (31-70) years. According to the study's findings, there are significant differences (p<0.05) between the vitamin D3, RF, and ESR groups. The mean levels of ESR and RF were highest in patients(84.05±33.79 and 17.35±5.08) than healthy (38.62±15.53 and 10.55±3.22) respectively. In contrast, the mean levels of vitamin D3 was lowest in patients (21.00±9.68) than healthy (32.40±13.45). The conducted study showed there is no significant difference (p>0.05) between ESR and RF among age groups of patients, but we found there is significant different between vitamin D3 among groups, where >70 and 41-50 years scored highest mean (31.37±9.80 and 23.96±8.82), while 31-40 and 61-70 years scored lowest mean (14.25±6.22 and 13.20±5.39) respectively. We conclude all these The majority of people with rheumatoid arthritis have a vitamin D deficiency, which is one of the factors that contributes to the severity of the disease, according to the research and current study's findings. Vitamin D deficiency in rheumatoid arthritis patients is caused by a lack of vitamin D intake from food sources, insufficient sun exposure, a disorder that impairs vitamin D absorption, and other factors

Phosphatidylinositol 3-kinase signaling pathway and inflammatory bowel disease: Current status and future prospects

المجلة: wileyonlinelibrary.com/journal/fcp

سنة النشر: 2023

تاريخ النشر: 2023-03-26

Inflammatory bowel disease (IBD) is a chronic life-limiting disease of gastrointestinal tract characterized by widespread enteric inflammation. IBD is a multifactorial disease, and different environmental, microbial, and immunerelated factors give rise to the development of disease. Among several factors, the preponderance of pro-inflammatory T helper 17 cells over the antiinflammatory regulatory T cells augments inflammation in the intestinal mucosa. Prevailing evidence accentuates that PI3K signaling pathway plays a central role in the pathophysiology of the condition by regulating the inflammatory process in the gut mucosa. By recognizing the implications of PI3K in the pathogenesis of IBD, agents that could modulate this pathway have recently been at the focus of research, yielding encouraging results mainly in the experimental IBD models. In this review, we have summarized the recent advances, which may hold the keys to identify novel therapeutic strategies for IBD.

Study of the effect of Metformin drug on folic acid levels in patients with type 2 diabetes

المجلة: Journal of Pharmaceutical Negative Results

سنة النشر: 2022

تاريخ النشر: 2022-07-26

Objectives: Diabetes is a major public health issue that has a significant negative impact on both communities and people. The best treatment for diabetes is metformin, which has the advantage of lowering death rates from all causes, cancer risk, and macrovascular diseases. Despite the fact that metformin is often used and extensively researched, there have only been a small number of randomized controlled studies to examine its effects on folate. In addition, it is yet unclear if short-term medication contributes to vitamin insufficiency. We hypothesize that even a brief period of metformin therapy causes folate levels to drop. However, given that metformin affects vitamins in people with type 2 diabetes, adding folate to the diet may be beneficial. Methods: 30 people with type 2 diabetes were investigated. physical examination, thorough medical history, and fasting blood samples. After a 12-hour fast, all blood samples were taken. Results: Our results showed that there is a direct effect of metformin on the deficiency of folic acid, as the level of folic acid decreased in the group of patients compared to the control group and it was significant . There is also an inverse relationship between folic acid and glucose in the group of patients. Conclusions: Metformin lowers folic acid levels in people with type 2 diabetes. Investigations are still being done on the therapeutic relevance of these results.

IMMUNOHISTOCHEMISTRY OF GALECTIN-3 (GAL-3) AND THYROID PEROXIDASE (TPO) MARKERS IN RELATION TO GENDER AND AGE IN PAPILLARY THYROID CARCINOMA (PTC) PATIENTS IN IRA

المجلة: EXECUTIVE EDITOR

سنة النشر: 2022

تاريخ النشر: 2022-07-26

Papillary thyroid carcinoma (PTC)is one of the most common tumors in Iraq.The incidence of females is more than males, The confirmation the validity of the tumour and its type was the aim of this research by using Gal-3 and TPOimmune markers to find the correlation between them and the diagnosis ofPTC Twentynine tissue samples from male and female papillary adenocarcinomas were used to find the correlation between Gal-3 and TPO for use in diagnosing tumors. We findpositive correlation between these immune markers and gender with thyroid papillary carcinoma ( PTC ).

629 (629-635) Adeeb, Zainab -A Particle Study …… Special Issue for the Researches of the 5 th Int. Sci. Conf. for Creativity for 13-14 December 2023 A practical study to evaluate the role of amylase among diabetics patients who visit health centers in

المجلة: Al-kut university jounal

سنة النشر: 2024

تاريخ النشر: 2024-07-26

Abstract Diabetes mellitus is a pancreatic endocrine condition brought on by insufficient insulin synthesis and/or resistance to the hormone's effects. Its endocrine and exocrine parts are closely related anatomically and functionally, both directly and indirectly. Thus, we are investigating the role of serum amylase in Type 2 Diabetes (DM). The study's goals are to determine the serum amylase levels in type-2 diabetes mellitus patients and to establish a correlation between those patients' serum amylase levels and HbA1c levels. Studying serum amylase levels in people with type-2 diabetes mellitus and establishing a correlation between serum amylase levels and HbA1c levels in these patients are the goals and objectives

A chemical-pathological study to evaluate the role of vitamin D, ESR, and RF and the prevalence of rheumatoid arthritis and its correlation with disease activity in the centers of Dhi Qar Governorate

المجلة: International Journal of Case Reports

سنة النشر: 2024

تاريخ النشر: 2024-04-26

This study assesses the correlation between vitamin D levels, Erythrocyte Sedimentation Rate (ESR), Rheumatoid Factor (RF), and the prevalence of Rheumatoid Arthritis (RA) in Dhi Qar Governorate, exploring their association with disease activity. Sixty individuals with RA and a control group of twenty healthy individuals were analyzed for vitamin D3, ESR, and RF levels. Results indicated significant differences between the groups, with RA patients showing higher ESR and RF levels and lower vitamin D3 levels. The study underscores the potential influence of these biomarkers on RA disease activity and suggests the necessity for further research into their roles in RA management.

A histopathological study to evaluate the role of immunohistochemical technique for evaluating follicular thyroid cancer among cancer patients in Dhi Qar Governorate

المجلة: International Journal of Advanced Research in Medicine

سنة النشر: 2024

تاريخ النشر: 2024-07-26

Despite rising rates of well-differentiated thyroid cancer, follicular thyroid carcinoma is becoming less common. This paper examines the evolution of morphological and immunohistochemical diagnostic criteria to explain why this phenomenon occurred. Follicular thyroid tumors. This article will cover the differences between follicular carcinoma, follicular adenoma, follicular variant of papillary carcinoma, and poorly differentiated carcinoma. It will also discuss the newly defined categories of follicular tumors: follicular tumor of uncertain malignant potential, welldifferentiated tumor of uncertain malignant potential, and well-differentiated carcinoma, not otherwise specified. Finally, interesting molecular biomarkers will be examined in relation to histopathological categorization for their prognostic and therapeutic implications.

Metastasis of cervical cancer cell line affected by probiotics in real-time PCR assay

المجلة: International Journal of Advanced Research in Medicine

سنة النشر: 2024

تاريخ النشر: 2024-08-16

Objective: The term "probiotic" refers to live microorganisms that have been linked to advantageous outcomes for the host. Nonetheless, a large body of research suggests that probiotic lactic acid bacteria (LAB) may be helpful in preventing colon cancer in its early stages. However, nothing is known about how probiotic LAB may affect colorectal and cervical cancer in their later phases, particularly with regard to metastasis. The present research sought to examine the impact of Lactobacillus crispatus supernatant (LCS) on cervical cell lines derived from human tissue, specifically focusing on the HeLa cell line. Throughout our inquiry, this was going to be executed. Materials and Methods: Using the MTT test, the experiment's activities impact of the LCS was ascertained. Through the utilization of a quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), an investigation into the expression of the MMP2 and MMP9 genes was carried out after the cells had been synchronized

Understanding the link between diabetes mellitus and fatty liver disease: A narrative review

المجلة: International Journal of Chemical Studies

سنة النشر: 2024

تاريخ النشر: 2024-08-15

Non-alcoholic fatty liver disease (NAFLD) is very common in people with type 2 diabetes mellitus (T2DM). This is probably because people with T2DM are often overweight and have trouble using insulin. People with type 1 diabetes (T1DM) can also have NAFLD, but it is important to tell the difference between the two. Glycogen hepatopathy is more common in people with T1DM and can cause hepatomegaly and problems with liver function. People with diabetes who are overweight or fat can avoid or treat NAFLD by losing weight through diet and exercise. People with T2DM who have NAFLD can also get better with bariatric surgery. New weight loss drugs should also be studied to see how they affect the growth and spread of NAFLD. A few studies show that statins and some drugs used to treat T2DM (such as TZDs, GLP-1 analogs, and DPP-4) inhibitors) may help diabetes people avoid or treat NAFLD. Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD) are spreading quickly around the world. Soon, they will be found in every country. There is a link between them because of metabolic risk factors like being overweight, having insulin resistance (IR), and living a poor life. It increases the chance of both liver and heart problems. Some patients feel bad about using the term "NAFLD," but not all of them do. Soon, a more useful one will be released. Medical treatments can work on both diseases at the same time because their main pathophysiological process is the same. Lifestyle changes, drug choices (as more molecules designed for treating T2DM may also help with NAFLD), and surgery are some of the strategies that can be used. This review is mostly about how NAFLD and T2DM can happen together, such as how to use the right words, how common it is, and how many diabetics die from it. To sum up, we've talked about the main pathophysiological processes, the risk stratification method for NAFLD and nonalcoholic steatohepatitis (NASH), and the tools that are used to measure fibrosis. Last but not least, we looked at the different ways that NAFLD linked to T2DM can be treated right now.

Metastasis of cervical cancer cell line affected by probiotics in real-time PCR assay

المجلة: International Journal of Advanced Research in Medicine

سنة النشر: 2024

تاريخ النشر: 2024-08-26

Abstract Objective: The term "probiotic" refers to live microorganisms that have been linked to advantageous outcomes for the host. Nonetheless, a large body of research suggests that probiotic lactic acid bacteria (LAB) may be helpful in preventing colon cancer in its early stages. However, nothing is known about how probiotic LAB may affect colorectal and cervical cancer in their later phases, particularly with regard to metastasis. The present research sought to examine the impact of Lactobacillus crispatus supernatant (LCS) on cervical cell lines derived from human tissue, specifically focusing on the HeLa cell line. Throughout our inquiry, this was going to be executed.

Understanding the link between diabetes mellitus and fatty liver disease: A narrative review

المجلة: International Journal of Chemical Studies 2024; 1

سنة النشر: 2024

تاريخ النشر: 2024-08-26

Non-alcoholic fatty liver disease (NAFLD) is very common in people with type 2 diabetes mellitus (T2DM). This is probably because people with T2DM are often overweight and have trouble using insulin. People with type 1 diabetes (T1DM) can also have NAFLD, but it is important to tell the difference between the two. Glycogen hepatopathy is more common in people with T1DM and can cause hepatomegaly and problems with liver function. People with diabetes who are overweight or fat can avoid or treat NAFLD by losing weight through diet and exercise. People with T2DM who have NAFLD can also get better with bariatric surgery. New weight loss drugs should also be studied to see how they affect the growth and spread of NAFLD. A few studies show that statins and some drugs used to treat T2DM (such as TZDs, GLP-1 analogs, and DPP-4) inhibitors) may help diabetes people avoid or treat NAFLD. Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD) are spreading quickly around the world. Soon, they will be found in every country. There is a link between them because of metabolic risk factors like being overweight, having insulin resistance (IR), and living a poor life. It increases the chance of both liver and heart problems. Some patients feel bad about using the term "NAFLD," but not all of them do. Soon, a more useful one will be released. Medical treatments can work on both diseases at the same time because their main pathophysiological process is the same. Lifestyle changes, drug choices (as more molecules designed for treating T2DM may also help with NAFLD), and surgery are some of the strategies that can be used. This review is mostly about how NAFLD and T2DM can happen together, such as how to use the right words, how common it is, and how many diabetics die from it. To sum up, we've talked about the main pathophysiological processes, the risk stratification method for NAFLD and nonalcoholic steatohepatitis (NASH), and the tools that are used to measure fibrosis. Last but not least, we looked at the different ways that NAFLD linked to T2DM can be treated right now.