Immunohistochemical Evaluation of Bcl-2 in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of Salivary Glands

المجلة: Journal of International Dental and Medical Research

سنة النشر: 2020

تاريخ النشر: 2020-01-01

Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Most start in the parotid glands. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. Adenoid cystic carcinoma is usually slow growing and often appears to be lowgrade when looked at under the microscope. Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. Objectives: To evaluate the hisopathological immunopositivity of Bcl-2 in Mucoepidermoid carcinoma and Adenoid cystic carcinoma and compare the results with Clinicopathological parameters and histological grades by using immunohistochemistry. Thirty cases have been studied histologically, (15) cases of Mucoepidermoid carcinoma and (15) cases of Adenoid cystic carcinomas were randomly retrieved for the period (2014 – 2018) the archives were obtained from the Specialist Surgeries Hospital, Medical city, Baghdad, Iraq Iraq. The correlations between the clinical and pathological parameters were statistically analyzed by Chi-square test the expressions of K-i67 antigen were evaluated and the level of significance was 0.05 (two-sided). All patients were included in this study 15 (50%) men and 15 (50%) women. Men to women ratio was 1:1. The average age of patients was 52.3 years ranged (23-71 years) in males and 46.8 years ranged (35-57 years) in females. The palate was the most common site followed by the parotid gland and the other sites. For MEC 4(26.7%) cases were grade (I), 3(20%) cases were grade (II) and 8 (33.3%) cases (33.3%) were grade (III). While for ACC 6(40%) cases were grade (I), 7 (46.7%) Cases were grade (II) and 2 (13.3%) Cases were grade (III). In Two tumors cases, Positive Bcl-2 expression was observed in all studies cases with variable extent of immunostaining except 2(6.7%) cases were negative expression.

Clinical Review and Management of Oral Potentially Malignant Disorders with Epithelial Dysplasia

المجلة: Journal of Health and Medical Sciences

سنة النشر: 2021

تاريخ النشر: 2021-11-10

It is critical to research the patients' unique characteristics, which include psychological, genetic, dietary, and dental problems. When epithelial dysplasia is present in an oral lesion, it is termed a precancerous lesion. Oral potential malignant diseases with epithelial dysplasia may or may not develop into carcinoma and may or may not be recurrent.