Association of interleukin6 rs1800796 gene polymorphism and serum level with bladder cancer in Egyptian population

المجلة: Molecular Biology Reports

سنة النشر: 2024

تاريخ النشر: 2024-07-15

Abstract Background Urinary bladder cancer (UBC)is a common tumor of the urinary tract. Objectives ToassessthediagnosticsignificanceofIL6rs1800796genepolymorphismandIL6serumlevelamongEgyptian patients with UBC. Design and methods One hundred patients with UBC were selected from the Mansoura Urology and Nephrology Center, in addition to 100 healthy control subjects; using PCR and ELISA techniques for IL6 detection. Results The rs1800796 GC, CC genotypes, and C allele were significantly more prevalent in the cases with bladder cancer compared to the healthy group (p < 0.001, = 0.021, < 0.001 respectively). There was a clear association between elevated levels of IL6 and bladder cancer versus the control group (median = 4.2, 0.89 respectively, p < 0.001). Serum IL6 levels showed significantly higher levels in patients carrying CC, followed by GC then GG genotypes. No significant association was found between IL6 rs1800796 gene polymorphism or serum level with demographic or laboratory data. Conclusion ItissuggestedthatthereisaclearlinkbetweenelevatedIL6levelsaswellasIL6rs1800796genepolymorphism with bladder cancer, suggesting their potential utility as biomarkers for the disease.