منصة إيفاد العلمية

مروة مالك كامل

إرسال رسالة

التخصص: ماجستير صيدلة

الجامعة: المستنصرية

النقاط:

16.5

معامل الإنتاج البحثي

الخبرات العلمية

Iraqi patent no 8274
Iraq patent no. 8277

الأبحاث المنشورة

Highly Porous 3D Printed Scaffold Incorporated with Graphene Oxide-Merwinite and Coated with IGF1 Loaded Nanofibers for Calvarial Defect Repair

المجلة: Journal of Polymers and the Environment

سنة النشر: 2024

تاريخ النشر: 2024-05-01

Critical-sized calvarial bone defects remain a significant challenge in orthopedic surgery, especially for irregularly shaped bones. Herein, we devised a customizable scaffold using a combination of 3D-printing and salt leaching techniques. Polycaprolactone (PCL), sodium chloride, and a graphene oxide-merwinite (GOM) nanocomposite were 3D-printed and then immersed in water to remove residual salt. Subsequently, gelatin-based electrospun nanofibers incorporating insulin-like growth factor-1 (IGF1) were applied to the PCL-GOM scaffold. The addition of 15% of GOM nanoparticles to the PCL scaffold increased the compressive strength from 2.2 to 3.8 MPa and the elastic modulus from 17.2 to 29.8 MPa. Apatite precipitates were well formed on the fabricated scaffolds after 28 days of immersion in simulated body fluid. Moreover, the scaffold displayed a gradual release of IGF1 over 28 days. The MTT assay demonstrated non-toxicity of scaffolds towards the MG63 cell line. Interestingly, significantly higher expression of Collagen I, RUNX2, and Osteocalcin were observed in qRTPCR results. Following implantation in calvarial bone defect for 8 weeks, the optimal scaffold demonstrated excellent osteogenic behavior and new bone tissue formation. This work presents a promising biomaterial with potential clinical applications for the treatment of irregular critical-sized bone defects.

A novel antioxidant and antimicrobial food packaging based on Eudragit ®/collagen electrospun nanofiber incorporated with bitter orange peel essential oil

المجلة: LWT - Food Science and Technology

سنة النشر: 2024

تاريخ النشر: 2024-02-01

A novel nanofiber for potential use in food packaging was developed by blending Eudragit ® (Eu) and collagen (Co) at varying ratios. Among these blends, Eu/Co nanofiber with a 70:30 ratio was identified as the optimal composition due to its bead-free morphology, fine fiber diameter (279.6 nm), high tensile stress (6.9 MPa), desirable water contact angle (WCA) of 72.18°, low water vapor transmission rate (WVTR) of 423.51 g/m2 × 24 h, and favorable porosity (65.4%). To further enhance its properties, bitter orange peel essential oil (BE) (up to 100 μL/mL) was incorporated into the optimal blend, resulting in a reduced fiber diameter (211.6 nm), increased tensile stress (8.5 MPa), and enhanced porosity (73.5%). Moreover, BE induced potential antimicrobial and antioxidant activities in the nanofibers, effectively inhibiting the growth of E. coli and S. aureus bacteria while scavenging up to 50% of DPPH radicals, respectively. Importantly, none of the nanofiber samples exhibited cytotoxicity toward Human umbilical vein endothelial cells (HUVEC) over a 72-h period, demonstrating their biocompatibility. These findings highlight the suitability of Eu and Co-based nanofibers enriched with bioactive compounds like BE for use in food packaging applications.

A novel designed nanofibrous mat based on hydroxypropyl methyl cellulose incorporating mango peel extract for potential use in wound care system

المجلة: International Journal of Biological Macromolecules

سنة النشر: 2024

تاريخ النشر: 2024-02-01

Skin tissue is damaged by factors such as burns, physical injuries and diseases namely diabetes. Infection and non-healing of burn wounds and lack of angiogenesis in diabetic wounds lead to extensive injuries and death. Therefore, the design of wound dressings with antibacterial and restorative capabilities is very important. In this study, nanofibers (NFs) including polyurethane (PU) and hydroxypropyl methyl cellulose (HPMC) were prepared with different ratios and Mango peel extract (MPE) loaded into NFs by electrospinning method. The morphology, chemical structure, porosity, degradation, water vapor permeability, mechanical properties, wettability, antioxidant activity and some cell studies and evaluation of their antibacterial properties were investigated. The optimal mat (PU90/HPMC10) had a defect-free morphology with homogeneous NFs. Furthermore, it showed improved biodegradability, water vapor permeability and porosity compared to other Mats. All NFs were non-toxic with hydrophilic behavior in the cellular environment and had acceptable hemocompatibility. The PU90/HPMC10/20 % optimal scaffold had significantly higher cell viability and proliferation than other samples and also had a higher antibacterial ability against pathogenic bacteria S. aureus (17 mm) and E. coli (11 mm). All these findings confirm that the produced NF mats, especially those loaded with MPE, have a high potential to be used as an effective wound dressing.

The effect of κ-carrageenan and ursolic acid on the physicochemical properties of the electrospun nanofibrous mat for biomedical application

المجلة: International Journal of Biological Macromolecules

سنة النشر: 2023

تاريخ النشر: 2023-09-01

Wound dressing materials such as nanofiber (NF) mats have gained a lot of attention in recent years owing to their wonderful effect on accelerating the healing process and protection of wounds. In this regard, three different types of NF mats were fabricated using pure polyvinylpyrrolidone (PVP), PVP/κ-carrageenan (KG), and ursolic acid (UA) in the optimal PVP/KG ratio by electrospinning method to apply them as wound dressings. The morphology, chemical structure, degradation, porosity, mechanical properties and antioxidant activity of the produced NFs were investigated. Moreover, cell studies (e.g., cell proliferation, adhesion, and migration) and their antibacterial properties were evaluated. Adding KG and UA reduced the mean diameter size of the PVP-based NFs to ∼98 nm in the optimal sample, with defect-free morphology. The PVP/KG/UA 0.25 % exhibited the highest porosity, hydrophilicity, and degradation rate and a wound closure rate of 60 %, 2.5 times higher than that of the control group. Furthermore, this sample's proliferation and antibacterial ability were significantly higher than the other groups. These findings confirmed that the produced UA-loaded NFs have excellent properties as wound dressing.

Co-Milling: A Successful Approach to Enhance Solubility of aPoorlySoluble Antihypertensive Drug

المجلة: Indonesian Journal of Pharmacy

سنة النشر: 2023

تاريخ النشر: 2023-09-23

The aim of the work was to enhance the solubilization of olmesartan-medoxomil (OM) and formulate stable, fast-dissolving-tablets (FDTs) formulations. However, OM is classified as a Biopharmaceutics Classification System (BCS) Class II drug, which indicates that it is characterised by poor solubility. Therefore, boosting its solubilization has the potential to boost its bioavailability. For the OM evaluation, a new HPLC technique was developed and then validated in accordance with international standards such as International Conference Harmonisation (ICH) and Food and Drug Administration (FDA) guidance. Twelve FDT-formulations were prepared using co-milling with superdisintegrants such as croscarmellose sodium (Ac-Di-Sol) and Crospovidone type A in varied percentages, followed by mixing with pH-adjusting substances such as calcium carbonate to increase solubilization in cases where the drug is soluble in alkaline. Following the evaluation of the created formulations, the optimised formulations were selected for further stability assessment. Co-milling process with Crospovidone greatly improved the OM release. The optimised formulations were OD11 and OD12, which exhibited fast disintegration, and the release exceeded 90% within 10 min, while the release for OM pure standard was 9.8% after 10 min. The OD11 and OD12 were chosen for further stability assessment and revealed good stability behaviour, as the study on optimised formulations revealed that the degradation was less than 5% after storage for six months at 40 °C and 75% relative humidity. Some formulations exhibited good results in terms of disintegration and release. To sum up, co-grinding with Crospovidone could increase the solubilization of OM.

Advanced Mesoporous Silica Nanoparticles: Synthesis, Characteristics and Applications

المجلة: Maaen Journal for Medical Sciences

سنة النشر: 2023

تاريخ النشر: 2023-08-16

Recent breakthroughs in pharmaceutical delivery methods employing a range of carriers have radically transformed modern diagnostic and therapeutic practices. Mesoporous silica nanoparticles (MSNs) were created due to the demand for substances with superior thermal and chemical capabilities. These ordered porous substances have generated a lot of interest as carriers due to their distinct advantages over the competition. They may be made economically using a simple process. Moreover, the shape, pore size, and particle size may all be changed by modifying the synthesis's conditions. Investigations on MSNs as drug carriers have reportedly accelerated in recent years, highlighting the potential benefits of such a drug delivery approach. MSNs have proven to be effective transporters for anticancer, anti-inflammatory, and neurological medications. This review discusses the origin, synthesis, and most recent applications of MSN

Preparation and evaluation of famotidine nanosuspension

المجلة: Al Mustansiriyah Journal of Pharmaceutical Sciences

سنة النشر: 2018

تاريخ النشر: 2018-07-25

Famotidine (FM) is a potent H2-receptor antagonist used for the treatment of peptic ulcer. It has a low and variable bioavailability which is attributed to its low water solubility. There are many methods used to increase dissolution rate of drug and in this study, the dissolution of the drug was enhanced by the preparation of nanosuspension. Famotidine nanosuspension was prepared by antisolvent precipitation method, where famotidine dissolved in methanol at room temperature and emptiedinto water containing different types of stabilizers (single and in combination). The optimum formula (F9) was selected according to particle size (362.8nm) and release profile (80 % of drug release within the 10 minutes) in comparison to pure famotidine powder release. The influence of formulation variables like the type and concentration of stabilizers Polyvinyl pyrrolidone K30, polyvinyl alcohol and poloxamer 188 (PVP K-30, PVA and poloxamer 188) in addition to combination of stabilizers on particle size of drug nanosuspensions were studied. The result showed that single stabilizer (poloxamer 188) has perfect surface affinity and could form a substantial mechanical and thermodynamic barrier at the interface of dug molecule. As the concentration of stabilizer increases the particle size decreases at fixed drug concentration (drug: stabilizer ratio 1:2).