Interleukins profile among patients infected with ocular toxoplasmosis in Baghdad city, Iraq

المجلة: Samarra Journal of Pure and Applied Science

سنة النشر: 2024

تاريخ النشر: 2024-06-30

Toxoplasma gondii is an intracellular organism that causes serious illness in both animals and people all over the world. It is often asymptomatic, but in immunocompromised people, it can cause pneumonia, ocular toxoplasmosis, and even mis1carriages. Research into T. gondii in cancer patients is extensive. However, no one has yet discussed the implications of widespread parasite infection in this population. Ocular toxoplasmosis (OT) is the infection of the eye caused by toxoplasmosis. Toxoplasma gondii infection, which causes infectious posterior uveitis and consequent vision loss, is a significant health damage, particularly in developing nations.

IL10 Gene Polymorphism and Its Association with Ocular Toxoplasmosis Susceptibility.

المجلة: African journal of biological science

سنة النشر: 2024

تاريخ النشر: 2024-05-20

Toxoplasmosis of the eye can induce visual changes, retinochoroiditis, and in some cases, blindness. Infection with T. gondii stimulates T helper 1 cells to produce IL-10, a cytokine implicated in toxoplasmosis resistance. The association between OT and the GG genotype at the IL-10 promoter SNPs suggests that abnormalities in the genetic regulation of cytokine levels may have an impact on the human immune response in OT. IL-10 is an anti- inflammatory and immune-regulatory cytokine that induces T cell anergy by downregulating the expression of genes encoding the costimulatory molecule B7-1/B7-2, major histocompatibility complex (MHC) class II, proinflammatory cytokines (IFN-, TNF-, and IL-12), and chemokines secreted by activated macrophages. The serum level of IL-10 of the group was highly significant increased in O.T. patients than controls, (264.65 ± 19.8 vs. 123.77 ± 6.1 pg/ml), (P= < 0.001), As well as, the serum level of IL-10 of the group was non- significantly increased in A.T. patients than controls, (156.82 ± 16.3 vs. 123.77 ± 6.1 pg/ml), (P= 0.048), On the other hand, the serum level of IL-10 of the patients groups was highly-significant increased in O.T. patients than in A.T., (264.65 ± 19.8 vs. 156.82 ± 16.3 pg/ml), (P= < 0.001) .

EFFECT OF THE OBESITY ON INTERLEUKIN-6 AND REACTIVE OXYGEN SPECIES.

المجلة: Biochemical & Cellular Archives,

سنة النشر: 2020

تاريخ النشر: 2020-01-20

Obesity is defined as abnormal or excessive fat accumulations that may impair health include fertility. The most common way to evaluate fat accumulation is through the Body mass index (BMI), which is calculated using personâ€TMs weight in kilograms divided by the square of his height in meters (kg/m2 ). The study was carried out on 80 men (60 are patients with BMI >30 and 20 as a control with BMI < 30) with age range (20-60) years. There is a significant (P<0.0001) increase in level of Body mass index (BMI) (34.78 ± 4.1 kg/m2 ) in patient group comparison to control group (27.9 ± 2.4 kg/m2 ). The level of interleukin6 (IL-6) is increase in patients (P < 0.01, 4.31 ± 2.8ng/ml) comparing to control (1.95 ± 0.96ng/ml). The mean level of Reactive oxygen species (ROS) significant (P< 0.01) increase (633.16 ± 568.9) comparing to control (254.78 ± 108.74).

Exploring IgA variation in serum and aqueous humor of ocular toxoplasmosis patients: relevance for radiotherapy VMAT strategies

المجلة: Oncology and Radiotherapy

سنة النشر: 2023

تاريخ النشر: 2023-11-30

Toxoplasma.gondii is a protozoan eukaryotic parasite that can enter the body host as an obligate intracellular parasite and causes toxoplasmosis infection, it has the ability to cause latent infection in the host tissue such as cardiac muscle, skeletal muscles, or the central nervous system (Mendez et al.2017). Research into T. gondii in cancer patients is extensive. However, no one has yet discussed the implications of widespread parasite infection in this population. (Tarabulsi., 2020). Ocular toxoplasmosis (OT) is the infection of the eye caused by toxoplasmosis. Toxoplasma gondii infestation, which causes infectious posterior uveitis and consequent vision loss, is a significant health damage, particularly in developing nations (ADEGBEHINGBE, 2020). The study was carried out on 80 sample (50 are patients and 30 as a control) with age range (15-65) years, The serum level ( S.IgA) of the group was non-significantly increased in O.T. patients than controls, (107.84 ± 11.1 vs. 93.39 ± 9.67 pg/ml), (P= 0.329) . As well as, the serum level of S.IgA of the group was non-significantly increased in A.T. patients than controls, (100.06 ± 8.03 vs. 93.39 ± 9.67 pg/ml), (P= 0.607) . On the other hand, the serum level of S.IgA of the patients groups was non- significantly increased in O.T. patients than in A.T., (107.84 ± 11.1 vs. 100.06 ± 8.03 pg/ml), (P= 0.573). The level of Aqueous homer (A.IgA) of the group was significantly increased in O.T. patients than controls, (226.25 ± 12.14 vs. 191.78 ± 9.8 pg/ml), (P= 0.03) . As well as, the level of A.IgA of the group was non- significantly increased in A.T. patients than controls, (198.16 ± 12.4 vs. 191.78 ± 9.8 pg/ml), (P= 0.155) . On the other hand, the level of A.IgA of the patients groups was non-significantly increased in O.T. patients than in A.T., (226.25 ± 12.14 198.16 ± 12.4 pg/ml), (P= 0.112).