Effect of Albendazole and Mebendazole on hydatid cyst of mice

المجلة: Open Journal of Epidemiology

سنة النشر: 2017

تاريخ النشر: 2017-10-17

In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p < 0.01). Inside the mice, small number of cysts was noticed in the group treated with albendazole and mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.

In Vivo and In Vitro Survival Rates of Protoscoleces Kept at Different Constant Temperature

المجلة: Open Journal of Epidemiology

سنة النشر: 2017

تاريخ النشر: 2017-08-16

ABSTRACT An experiment was conducted on the survival rate of protoscoleces derived from hydatid cyst brought from infected camels in Tambool area (North Eastern Sudan). The survival rate was studied in vivo and in vitro through exposure to different constant temperatures to measure their viability. The results revealed that the protoscoleces remained viable in vitro for 20 days at 4˚C, 7 and 5 days at 25˚C and 37˚C, respectively, while at 45˚C the protoscoleces were immediately dead. This means that the infection rate of hydatid cyst becomes high in relatively cold seasons (winter and autumn). In the in vivo study, each mouse (five groups, four mice in each) was inoculated intraperitoneally with 2000 protoscoleces exposed to the same different constant temperature, as previously used. 6 months later, the mice in different groups were sacrificed and necropsied to study the development of hydatid cyst inside. The results showed that the rate of development inside the mice was clear in the first and the second groups (4˚C and 25˚C), however, in the other 2 groups (37˚C and 45˚C), no sign of development of the cyst was observed, with the presence of few number of hooks compared to the control group, which showed significant difference in the development of hydatid cyst.

Field investigation on cystic hydatid infection in camel in Tambool town, Sudan

المجلة: American Journal of Biomedical Science and Research

سنة النشر: 2019

تاريخ النشر: 2019-10-22

The aim of this study was to evaluate the prevalence of the disease in camels in Tambool area, Sudan with emphasis on the number and stages of cysts in different organs. The investigation revealed 21.3% prevalence rate among camels.

In Silico Mining of Natural Products Atlas (NPAtlas) Database for Identifying Effective Bcl-2 Inhibitors: Molecular Docking, Molecular Dynamics, and …

المجلة: Molecules

سنة النشر: 2023

تاريخ النشر: 2023-01-12

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