Comparative study of Antibacterial activity of AgNPs and antibiotics

المجلة: مؤتمر كلية المصطفى الجامعة

سنة النشر: 2023

تاريخ النشر: 2023-05-01

twenty two sample of urine had been scanned for Urinary Tract Infection by bacteria ,seven sample were identified the infection of, E.coli. Antibiotic susceptibility had been scanned for bacterial isolates by five antibiotic discs ( Neomycin 30 mcg, Aztreonam 30 mg, Cefoxitin 30 mg, Meropenem 10 mg ,and Ciprofloxacin 5mg) . To obtain silver nanoparticles (AgNPs) in a liquid form at a concentration of 2000 mg /ml, we dissolved 0.02 gm of AgNPs powder in 10ml of distilled water, using Ultra Sonication bath VGT / China, This represents the stock. The antibiotic susceptibility had shown 7 isolate 100% was resist to the antibiotic Neomycin, Cefoxitin and Meropenem . The antibiotic susceptibility had shown 7 isolate 100% was high sensitive to the antibiotic Ciprofloxacin and Aztreonam . All seven isolate 100% was resist to the silver nanoparticles . The synergism effect between ciprofloxacin and AgNPs gave high activity against all E.coli isolates. Several studies must been done for see the ability of using silver nanoparticles as drug to reduce the using of antibiotics and to minimize antibiotics resistant by bacteria.

reveiw on Pseudomonas aeruginosa

المجلة: وقائع مؤتمر كلية المصطفى الجامعة

سنة النشر: 2021

تاريخ النشر: 2021-06-22

gees dompris serue nt the most biguis and diverse Gram-negative bacterial species in nature that are capable of utilizing a wide range of organic compounds and colonizing a variety of ecological niches in 2006-7 report by National Healtheare Safety Network (NHSN) at the Centers for Disease Control and Prevention ranked the bacterium as the sixth most common healthcare associated pathogen-causing infection. Also, it is typically found at even higher rank in studies focused on the intensive care unit and find out as the third Ilost continon pathogen associated with hospital- acquired catheter associated UTIs it has a tendency to form biofilms on the surface of urinary catheters and leading to captic invasiv ivectios in burelatiens 5 orall deaths burn wound infection. In addition to wounded skin injury, inalaton mary is common in burn patents. Eseuaomonas aeruginosa is the major cause of morbidity in cystic fibrosis when is denne as an auto-somal recerve geneue alsorder, une most common fatal genetic disease. Pathogenesis is mediated by multiple bacterial virulence factors that facilitate adhesion and/or disrupt host cell signaling pathways while targeting the extracenar matris nagenum, onus and non-onus danesins as well as with exoenzymes or secretory virulence tactors like protease, elastase, phopholipase, pyocyanin, exotoxinAr exoenzyme S, hemolysins (rhamnolipids) and siderophores. Early detection is critical for treating Pseudomonas aeruginosa infection. Scientists have long been committed to establishing a rapid and sensitive detection method for Pseudomonas aeruginosa. Currently, numerous modern detection approaches have been developed, such as Flow cytometry, immunological derecuon mernoos and molecular 010102y-based derecuon methods However, conventional culture methods are still the most commonly applied methods in clinical practice at present